Trials

The study will include three randomized-cluster trials (RCTs) and one operational study (OR).

  • In Kenya, the AEGIS project will carry out an RCT to evaluate protection against new malaria infections and ongoing transmission in populations where bed nets and indoor residual spraying are already in use. Specifically, the AEGIS team will evaluate the spatial repellent's efficacy, quantify whether it diverts mosquitoes to neighboring households and assess its impact on insecticide resistance.
  • The second RCT in Sri Lanka will evaluate how effective the spatial repellent is against new human Aedes-borne virus infections, primarily dengue.
  • The third RCT in Mali will evaluate protection against new malaria infections and ongoing transmission in populations where bed nets and indoor residual spraying are already in use. Specifically, we will evaluate the spatial repellent's efficacy, and assess its impact on insecticide resistance.
  • The OR study will be conducted in Mali and Uganda to evaluate effectiveness against malaria infections among displaced persons, where long-lasting insecticidal nets and/or indoor residual spraying often cannot be used because of the lack of permanent homes.