Sri Lanka

Sri Lanka 2

This will be a cluster randomized, placebo controlled trial to evaluate the protection provided by Envelope against Aedes-borne dengue, Chikungunya and Zika virus (DCZV) transmission. The trial will be carried out in Colombo, Sri Lanka, which has active seasonal dengue transmission and well-established infrastructure for studying urban dengue fever. Efficacy will be measured through standard household monitoring of Aedes aegypti population densities, while Aedes borne virus transmission will be measured through door-to-door surveillance for active dengue disease and through serological monitoring for DCZV exposure.

Study Objectives:

  1. Demonstrate and quantify the protective efficacy of spatial repellent (SR) products in reducing the incidence of dengue infection in humans
  2. Confirm and measure the entomological correlates of reduced infection (e.g., a reduction in adult densities and parity rates).
  3. Evaluate the adoption, maintenance, and sustainability of the SR intervention in the trial clusters.
  4. Quantifying the total number of infections averted using the SR intervention.

Study Population and Location: The trial will occur in 5 contiguous Medical Officer of Health areas in the district of Colombo: Ratmalana; Egoda Uyana; Moratuwa; Dehiwela; and Maharagama, Sri Lanka. AEGIS will establish a cohort of 2,490 persons, primarily children 2-12 years of age and adults who have not been previously infected with DCZV who will provide annual blood samples when they are healthy. Additionally, AEGIS anticipates monitoring up to 19,747 residents for active dengue disease.

In-Country Project Lead: National Dengue Control Unit - Sri Lanka

Additionally, social science methodologies and health and market analyses will provide evidence for the acceptability and scalability of implementation. To ensure the SR product is adopted as a complementary vector control tool, findings will be disseminated to the scientific community, end users, and project stakeholders.